The zebrafish model is gaining relevance in pre-clinical trials due to its small size, transparency, ease to manipulate and rapid development. This model has a high genetic homology with humans (over 85%) as well as important parallels in organogenesis and functional mechanisms
Biobide has developed a method to detect the capability of a compound to inhibit angiogenesis as part of efficacy pharmacology studies. Angiogenesis, the development of new blood vessels from existing vasculature, is essential in normal diabetic retinopathy, psoriasis and tumor growth and metastasis. Thus, the molecular dissection of angiogenic signaling is clinically relevant.